Skip to main content
Fig. 4 | Genome Medicine

Fig. 4

From: Explaining decisions of graph convolutional neural networks: patient-specific molecular subnetworks responsible for metastasis prediction in breast cancer

Fig. 4

Signal transduction pathway analysis of subnetwork genes reported for 79 patients in 5 subtypes. (From left to right) Blue heatmap: 238 signaling pathways clustered according to proportion of shared subnetwork genes; Orange heatmap: Enrichment significance of pathways in subnetwork genes combined from patients of given subtype. Darker orange indicates higher significance; Purple heatmap: Median difference in matched pathway genes observed in pairwise comparisons of subnetwork gene sets from patients mapped to 33 pathways. Darker purple indicates higher tendency of pairs of subnetwork gene sets to coincide with different pathway genes; Green heatmap: Enrichment significance of pathways in subnetwork genes of 79 patients. Darker green indicates higher significance. Corresponding subtypes and metastatic status are shown by the annotation above the heatmap. A detailed version of this figure capturing pathway and sample names is provided in Additional file 1: Fig. S2

Back to article page

Genome Medicine

ISSN: 1756-994X

Contact us