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Table 2 Differentially abundant OTUs between NG and PD subjects from both Danish and Indian cohorts

From: Trans-ethnic gut microbial signatures of prediabetic subjects from India and Denmark

OTU IDs Taxonomic affiliation Log2 fold change Log2 FC standard error BH-adjusted p value Mean % abundance
Enriched in NG
 291725 Prevotella_9 − 1.7680 0.5088 8.88E−03 0.2918
 556835 Phascolarctobacterium faecium − 1.5371 0.4627 1.38E−02 0.2914
 190975 Barnesiella intestinihominis − 1.6235 0.4381 4.56E−03 0.0567
 335550 Flavonifractor plautii − 1.1188 0.3509 1.86E−02 0.0457
 4315782 [Family]Ruminococcaceae − 2.4732 0.7731 1.83E−02 0.0147
 659361 Tyzzerella_4 nexilis − 2.4165 0.8183 3.45E−02 0.0097
 583656 Bacteroides nordii − 1.7518 0.3759 1.97E−04 0.0092
 583256 Faecalibacterium − 1.7176 0.2714 5.54E−08 0.0087
 211935 Agathobacter − 1.0416 0.3203 1.66E−02 0.0086
 177679 [Family]Muribaculaceae − 1.4553 0.4535 1.79E−02 0.0048
 819181 Ruminococcaceae_UCG-002 − 1.0428 0.3378 2.38E−02 0.0033
 593008 Christensenellaceae_R-7_group − 1.7182 0.5400 1.88E−02 0.0033
 denovo32180 Ruminococcaceae_UCG-010 − 2.0100 0.7128 4.73E−02 0.0030
Enriched in PD
 817140 Megasphaera elsdenii 1.7989 0.3362 1.12E−05 1.1755
 349024 Streptococcus equinus/gallolyticus/infantarius/lutetiensis 2.0231 0.3458 7.59E−07 0.8744
 339221 Prevotella_9 1.4210 0.3933 6.20E−03 0.8176
 357046 Alistipes finegoldii/onderdonkii 1.3202 0.3080 8.10E−04 0.4661
 13811 Mitsuokella 1.3869 0.3688 4.05E−03 0.3890
 1111294 Escherichia/Shigella albertii/ boydii/coli/dysenteriae/fergusonii/flexneri/sonnei/vulneris 2.0982 0.3131 6.45E−09 0.3829
 264967 Megasphaera 1.9031 0.3591 1.21E−05 0.3539
 566899 [Family]Ruminococcaceae 1.0812 0.3529 2.50E−02 0.3489
 269937 Prevotella_2 2.5823 0.5627 2.47E−04 0.2158
 345899 Prevotella_9 1.5634 0.4830 1.69E−02 0.1898
 1767788 Vibrio cholerae 3.3938 0.6447 1.37E−05 0.1604
 denovo49732 Lactobacillus 1.1079 0.3289 1.21E−02 0.1374
 546557 Alloprevotella 2.5351 0.5821 6.27E−04 0.1229
 278795 Rhodococcus baikonurensis/ boritolerans/degradans/ erythropolis/globerulus/hoagii/ opacus/qingshengii/rhodochrous 1.1766 0.2996 2.43E−03 0.1102
 211191 [Family]Ruminococcaceae 1.0446 0.3314 1.99E−02 0.1033
  1. Differentially abundant OTUs between NG and PD subjects, belonging to the Indian and Danish cohorts (pooled together), identified using a negative binomial Wald test (corrected for geography-specific cohort effect). A positive log2 fold change value indicates higher relative abundance of the OTU in PD subjects and vice versa. P values were adjusted for multiple testing using Benjamini-Hochberg correction. Up to top 15 OTUs (sorted according to mean abundance values) which are at least twofold enriched (padj < 0.05) either in the NG or the PD group are listed