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Fig. 1 | Genome Medicine

Fig. 1

From: Phenome-wide investigation of the causal associations between childhood BMI and adult trait outcomes: a two-sample Mendelian randomization study

Fig. 1

a Schematic diagram of an MR analysis. Since genetic alleles are independently segregated and randomly assigned, SNPs are not associated with confounding factors that may bias estimates from observational studies. Three assumptions of MR are as follows: (1) the selected instrument is predictive of the exposure, (2) the instrument is independent of confounding factors, and (3) there is no horizontal pleiotropy (the instrument is associated with the outcome only through the exposure). b The analysis pipeline of the current study

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Genome Medicine

ISSN: 1756-994X

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