Fig. 3

Comparison of ASQM scores of overlapping or distinct genes on commercial panels. Box and whisker plot of ASQM scores of genes that appeared on all four commercial laboratory NBS panels, only three commercial panels, only two commercial panels, and only one commercial panel. The gray box represents the area where genes-disease pairs scoring 9, 10, or 11 could not be automatically categorized and necessitated further discussion by the scoring committee prior to final categorization. Distributions varied significantly across all panels by Kruskal–Wallis test (p < 0.0001), and paired Mann–Whitney U tests identified significant differences in three out of four comparisons between scores of genes on all four panels versus only two panels (*p = 0.429), scores of genes on all four panels versus only one panel (****p < 0.0001), scores of genes on three panels versus only one panel (****p < 0.0001), and scores of genes on two panels versus only one panel (***p = 0.0001)