Fig. 4

L83V and R175W variants cause behavioral defects in adult flies. a dAtad3a-null mutant flies expressing L83V, and R176W were short lived compared to wild-type rescue animals and wild-type control (w¹¹¹⁸). b dAtad3a-null mutant flies expressing L83V, and R176W exhibited progressive climbing defects compared to wild-type rescue controls and wild-type control (w¹¹¹⁸). c dAtad3a-null mutant flies expressing R176W exhibited defects in flight ability on the 5th day of their life and complete failure of flight on the 35th day. dAtad3a mutant flies expressing L83V exhibited progressive decline of flight ability compared to rescue control and wild-type control (w¹¹¹⁸). b, c Three biological replicates (25 flies per group) were quantified. Error bars indicate SEM. P values were calculated using Student’s t test. *P < 0.05, **P < 0.01,***P < 0.001. N.S. indicates not statistically significant