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Table 1 Main findings from trans-ethnic EWAS meta-analyses for 13 replicated DMPs

From: Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci

     Our study discovery Sample size by DNAm array Replication GS/CATHGEN/HyperGEN Combined discovery and replication
DMP Chr Position (hg38) Gene Effect p 450K EPIC 850 K Effect p Effect p
cg13235761^ 1 203,592,452   − 37.61 4.33E−06 3048 2378 − 25.28 5.08E−05 − 29.81 1.88E−09
cg26099045^* 2 64,064,666   14.82 5.74E−06 3050 2378 11.24 1.01E−04 12.81 3.26E−09
cg04428662^Ω* 4 2,932,461 MFSD10 − 30.84 3.21E−06 3049 2378 − 34.94 3.43E−07 − 32.82 5.51E−12
cg23174201^* 5 151,674,695 SPARC − 35.83 5.10E−06 3050 2378 − 34.87 1.72E−07 − 35.27 4.02E−12
cg17170437 6 44,229,461 SLC29A1 − 47.62 1.96E−06 N/A 2378 − 18.62 1.49E−04 − 24.24 3.80E−08
cg14871770 10 96,658,622 CYP2C9, CYPC19 − 53.12 1.98E−06 N/A 2378 − 25.87 1.70E−04 − 33.36 1.23E−08
cg02157636 11 68,709,367 TESMIN − 53.21 2.15E−06 N/A 2378 − 27.25 1.14E−05 − 33.33 8.58E−10
cg26039141^Ω 11 75,402,116 RPS3 − 39.14 3.40E−06 3050 2378 − 33.42 1.78E−05 − 36.06 2.90E−10
cg22593432^* 13 32,001,768   − 29.91 1.54E−07 3050 2378 − 17.66 1.79E−04 − 22.64 4.61E−10
cg11789371^* 14 102,085,048 HSP90AA1 − 35.40 4.44E−06 3050 2378 − 22.66 3.58E−04 − 27.80 1.41E−08
cg05796561 18 57,128,273   − 45.24 2.96E−06 N/A 2378 − 22.91 1.69E−04 − 29.24 1.41E−08
cg17944885^Ω* 19 12,114,920 ZNF20, ZNF788P − 32.71 1.41E−09 3048 2378 − 16.34 5.67E−07 − 20.72 1.24E−13
cg15787712^ 19 13,837,429 LOC284454, MIR23 − 37.60 6.00E−09 3050 2378 − 28.65 2.06E−05 − 33.30 9.01E−13
  1. p-value for replication < 6.4E−04 (Bonferroni correction for 78 DMPs tested). Four of the 13 DMPs that replicated were non-450K probes (cg17170437, cg14871770, cg02157636, cg05796561). Results from combined discovery and replication are also shown
  2. GS Generation Scotland, N/A not applicable
  3. ^cis-meQTL from the BIOS QTL [36, 37]
  4. ΩExpression quantitative trait methylation (eQTM) data from the BIOS QTL (enrichment p-value <0.01) [36, 37]
  5. *cis-meQTL in the Framingham Heart Study [38]