Fig. 3

Cell-specific and cell process enrichment analysis. a Gene-set cutoffs of partial correlation to associated gene as a function of standard deviations away from the mean partial correlation. These are the cutoffs used for cell type specific enrichments seen in c and d. b EnrichR cell process enrichments of APOC1 expanded gene set of the 50 highest partially correlated genes and then expanded to all protein interaction partners from the pathway commons database which are represented more than once (Left) and twice (Right). c Cell type specific enrichments of expanded gene sets using Lake et. al cell type specific marker gene sets. Grey denotes zero overlapping genes between gene set and cell type-marker gene set significance in a grey square infers depletion from the expected overlap by chance. d Cell type specific enrichments of expanded gene sets using Mathys et. al cell type specific marker gene sets