Fig. 3

Distribution of cancer driver genes and chromosome arm-wide aneuploidies. For each set of cancer types with shared tissue of origin, we plot: a the fraction of driver genes on each arm that are considered to be tumor suppressors (left column) and the frequency of losses reported for the arm. The bluer the color, the higher the tumor suppressor burden (and likewise for the frequency of losses. b The fraction of driver genes on each arm that are considered to be oncogenes (left column) and the frequency of gains reported for the arm (right column). The redder the color, the higher the oncogenic burden (and likewise for frequency of gains). Barplots shown beside each heatmap are the Spearman rank correlations (horizontal bars indicate comparisons for each arm independently; vertical bars indicate comparisons for each tissue independently). The size of bubbles indicates the p value. A size of 2 indicates p value < 0.01, a size of 1 indicates p value < 0.1, and size of 0 indicates p values < 1. As seen at the tissue level, correlation between tumor suppressor burden and frequency of losses is almost always positive (empirical p value after randomly shuffling data < 0.05), whereas that is not the case for gains