Fig. 6

Schematic presentation of the results. Genes on the red chromosomes are expressed at slightly higher levels compared to other chromosomes in normal tissue A, whereas in normal tissue B, the yellow chromosomes shows increased tissue-specific expression and genes on the green chromosome are expressed at lower levels. This results in a subtle increase or decrease in chromosome arm-wide gene expression levels, respectively. The acquisition of chromosomal aneuploidies in the respective cancer types (gain of the red chromosome in cancer type A and the yellow chromosome in cancer type B, accompanied by the loss of the green chromosome in cancer type B) amplifies this effect and provides the genetic basis of “hard-wiring” tissue-specific chromosome arm-wide gene expression levels as the basis for clonal expansion. The dots on the green chromosome reflects the presence of a tumor suppressor gene