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Table 2 Sample description for imputed genotype chip cohorts

From: Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program

Population

Cohort

N

Age

Percent female

BMI

Apnea-hypopnea index 3%

AHI (percent < 5, 5–15, ≥ 15)

Average desaturation

Average SpO2

Minimum SpO2

Percent sleep under 90% SpO2

African-American

CFS*

225

35.46 (20.32)

56.4

29.97 (10.09)

3.99 (10.55)

55.1, 23.1, 21.8

2.90 (1.09)

94.65 (4.01)

88.17 (9.60)

5.20 (16.01)

European-American, Australian

ARIC

631

62.74 (5.72)

49.4

29.15 (5.23)

9.15 (15.02)

29.3, 37.9, 32.8

2.50 (1.73)

94.32 (2.15)

85.17 (6.17)

4.12 (11.76)

CFS*

218

37.57 (18.66)

56.9

28.76 (8.11)

3.4 (10.59)

57.8, 22.5, 19.7

2.30 (1.11)

94.09 (3.35)

88.81 (7.80)

3.26 (12.79)

CHS

365

77.44 (4.65)

64.9

27.10 (4.41)

10.50 (15.14)

25.8, 39.2, 35.1

2.63 (1.57)

94.41 (1.91)

84.87 (5.96)

3.93 (11.89)

FHS*

192

57.45 (9.68)

51.0

28.87 (5.16)

7.30 (14.38)

38.0, 31.8, 30.2

2.42 (1.51)

94.73 (1.80)

85.76 (5.46)

2.82 (8.38)

MrOS

2181

76.65 (5.60)

0.0

27.21 (3.75)

13.00 (18.00)

18.9, 36.1, 45.0

3.54 (1.48)

93.85 (1.73)

84.39 (5.88)

4.40 (9.95)

WASHS

1508

52.29 (13.71)

40.9

31.84 (7.93)

7.24 (15.37)

40.1, 31.1, 28.8

3.56 (2.00)

94.56 (2.38)

84.61 (7.86)

5.44 (13.82)

Hispanic, Latino-American

HCHS, SOL

7155

46.10 (13.81)

57.8

29.68 (5.86)

2.00 (6.15)

69.1, 19.3, 11.6

N, A

96.46 (0.95)

87.06 (6.11)

0.83 (2.99)

Starr

782

52.34 (11.29)

71.9

32.15 (6.78)

10.35 (17.18)

31.5, 31.5, 37.1

N, A

94.65 (2.09)

85.78 (7.50)

2.83 (8.79)

  1. Eight studies contributed 13,257 individuals with genomic data imputed with a TOPMed Freeze 5b reference panel and objectively measured phenotypes (225 African-Americans, 5095 European-Americans, 7937 Hispanic/Latino-Americans). ARIC, CFS, CHS, FHS, and HCHS/SOL imputed genomic data reflect individuals without available sequencing in TOPMed Freeze 6. The overall sample had a mean age of 53.7 and was 46.9% female. Values are displayed as mean (SD), except for the skewed apnea-hypopnea Index, which is displayed as median (IQR). Sample size N reflects individuals with non-missing AHI and covariate values. *Family cohort