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Table 3 Lead gene-based multiple-population results

From: Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program

Phenotype Sex Gene B38 positions P N Variants Population P Population N Population variants
Avg desaturation All ARMCX3 X:101,623,082–101,625,765 3.48 × 10−8 5222 41 0.220, 0.179, 2.17 × 10−6, 8.93 × 10−4 1545; 227; 2994; 456 8, 5, 24, 9
All ARMCX3-AS1 X:101,623,082–101,625,153 3.49 × 10−8 5222 38 0.225, 0.179, 2.19 × 10−6, 8.20 × 10−4 1545; 227; 2994; 456 7, 5, 23, 8
Per90 All OR5K2 3:98,497,633–98,498,634 2.55 × 10−7 7986 7 0.143, 0.440, 4.14 × 10−2, 2.74 × 10−7 1712; 229; 3,242; 2803 4, 2, 1, 1
Per90 Females ZZEF1 17:4,004,409–4,144,018 4.22 × 10−7 4485 236 0.634, 0.337, 5.03 × 10−4, 3.05 × 10−5 1009; 114; 1702; 1660 85, 16, 87, 131
  1. Lead MMSKAT gene-based results meta-analyzed across populations within one order of magnitude of significance (p < 4.51 × 10−8) are shown. Population-specific information for each gene is displayed in the latter columns for AA, AsA, EA, and HA, respectively. Individual populations varied in the number of polymorphic variants available for testing (e.g., due to singletons or excessively common variants). ARMCX3-AS1 is a RNA gene that is anti-sense to the protein-coding ARMCX3 gene. Full results for genes with p < 0.01, including Ensembl-derived gene biotypes and descriptions, are provided in Additional file 1: Table S4. A list of individual variants comprising each gene is provided in Additional file 1: Table S6