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Fig. 6 | Genome Medicine

Fig. 6

From: High-grade serous tubo-ovarian cancer refined with single-cell RNA sequencing: specific cell subtypes influence survival and determine molecular subtype classification

Fig. 6

Identification of distinct sets of cancer cells. A, B t-SNE plots showing the annotated cancer cell subclusters generated by unaligned PCA methods (A) as well as the distribution of cancer cell subclusters across patients and different sampling sites (ovary, omentum, peritoneum) (B). C t-SNE visualisation of 6 tumour subclusters originating from patient 3 with mixed HGSTOC-clear cell histopathology. Tum_BAMBI, Tum_ARNT2, Tum_DNAH5 and Tum_PTPRZ1 lacked expression of WT1 suggesting a clear cell origin of these subclusters, while Tum_KRT6A represents the HGSTOC component. D Heatmap showing metabolic activity of the tumour subclusters. E t-SNEs with marker gene expression indicating an active EMT pathway

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Genome Medicine

ISSN: 1756-994X

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