Fig. 4

Amplification of chromosome 12p12.1. a Schematic view of the amplification targeting chromosome region 12p12.1 (chr12:22615401-26669741) identified in BoC106 C2. b Increased gene expression of KRAS and other genes within the amplified region, as measured by array expression profiling. 5dC, tumors treated for 5 days with CET and still sensitive to CET. C, tumors with SR under chronic CET treatment