Fig. 8

Mouse growth factors impair CET response. a Fold changes for selected GFs showing an increase in expression in SR tumors (C) relative to their corresponding tumors after 5 days of CET treatment (5dC). *, SR tumors with driver gene alterations. CR, complete response, PR, partial response, SD, stable disease. b–h Proliferation response of primary colon cancer cells BoC20 upon treatment with the indicated GFs (Fgf9: 19 ng/ml; Fgf10: 240 ng/ml, Fgf18: 100 ng/ml, Pdgfb: 10 ng/ml; Pdgfc: 700 ng/ml, Igf2: 10 ng/ml; Hbegf: 10 ng/ml) and CET (5μg/ml) alone or in combination measured via RTCA. GFs and/or CET were added at the indicated time point (arrow). All cell index measurements were taken in duplicates and are shown as mean values ± SD (error bars). A.U., arbitrary unit