Fig. 6

Kaplan-Meier analysis of codon, codon pair, and transcriptome changes in 596 patients. A Kaplan-Meier curves for patients with relatively high global codon usage changes (red) and patients with relatively low global codon usage changes (green). The horizontal dashed line represents 50% survival probability and intersects with each curve at their median survival time. Shaded regions represent 95% confidence intervals. B Kaplan-Meier curves for patients with relatively high global codon pair usage changes (red) and patients with relatively low global codon pair usage changes (green). The horizontal dashed line represents 50% survival probability and intersects with each curve at their median survival time. Shaded regions represent 95% confidence intervals. C Kaplan-Meier curves for patients with relatively high transcriptome changes (red) and patients with relatively low transcriptome changes (green). The horizontal dashed line represents 50% survival probability and intersects with each curve at their median survival time. Shaded regions represent 95% confidence intervals