Fig. 1
From: Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes
WGCNA [39] identifies 2 co-expression networks in the METSIM adipose RNA-seq cohort (n = 335), significantly correlated with WHRadjBMI and fasting serum insulin (A), discovery of the red WHRadjBMI co-expression network that is enriched for TFs and GWAS genes (B), and enriched for upregulated adipose tissue -specific DE genes when compared to other tissues in GTEx [41] (C). A The numbers in the cells represent Pearson correlation results of network eigengenes with BMI, WHR, and WHRadjBMI, and fasting serum insulin (adjusted for T2D status) with correlation coefficients and p values (shown in parenthesis). Associations that pass Bonferroni correction for the number of networks and traits tested (pBonf < 8.93 × 10−4) were considered significant. B Bar plot showing enrichment of TFs and GWAS genes in the red WHRadjBMI co-expression network (light gray) when compared to the black WHRadjBMI co-expression network (dark gray) using Fisher’s exact test. Significance of enrichment using Fisher’s exact test is indicated above each set of bars, pFisher. C Bar plot showing significant enrichment (red) of upregulated adipose tissue-specific DE genes in WHRadjBMI co-expression network using FUMA [75, 76] when compared to the 54 other tissues in the GTEx v8 cohort [41]. GTEx v8 tissues are ranked by enrichment from most enriched to least enriched with the first 25 most enriched tissues shown. The tissue enrichments passing a Bonferroni correction are shown in red, while the non-significant enrichments are shown in blue