De novo transcriptomic subtyping of colorectal cancer liver metastases in the context of tumor heterogeneity

Table 1 Clinicopathological characteristics of patients with resected CRLM in the in-house series

Clinicopathological variable		Patients (total n = 171)	%
Gender, male		106	62
Primary tumor location
	Proximal colon	36	21
	Distal colon	135	79
Primary tumor differentiation (unknown, n = 19)
	Well	25	15
	Moderate	107	63
	Poor	20	12
Nodal status primary tumor (unknown, n = 8)
	N0	50	29
	N1	62	36
	N2	51	30
Synchronous (within 6 months) liver metastasis		133	78
Previous resection/radiofrequency ablation of CRLM		39	23
Systemic oncological treatment prior to tumor sampling		156	91
	Neoadjuvant chemotherapy for this metastatic situation	131	77
	Previous chemotherapy before this metastatic situation	52	30
	Molecularly targeted treatment, previous or neoadjuvant	51	30
Radiofrequency ablation		22	13
R-status liver
	R0-resection	71	42
	R1-resection^a	91	53
	R2-resection^b	9	5
Extra-hepatic disease		40	23
Multiple CRLM analyzed (patients, tumors, samples)		47/141/158

^a1 mm resectional margin or lesions treated with radiofrequency ablation
^b Macroscopic residual tumor in liver (visible at surgery or by radiological examination)

ISSN: 1756-994X