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Fig. 2 | Genome Medicine

Fig. 2

From: Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus

Fig. 2

Colocalization of rs1837253 with DNA methylation levels for cg15557878 at TSLP. rs1837253 (red vertical bar, upper panel) is associated with DNA methylation levels at cg15557878 (orange vertical bar, upper panel). Box plots show DNA methylation levels (y-axes) for meCpGs by rs1837253 genotype (x-axes) in the vehicle (β = − 0.25; 95% CI − 0.21, − 0.30), and RV (β = − 0.26; 95% CI − 0.21, − 0.30) treatment conditions (lower panel). Purple vertical bars indicate the location of the remaining meCpGs co-localized with rs1837253, which was associated with asthma in all three GWASs used in the co-localization studies (pGWAS < 10−12). P values and FDR adjusted P values (Padj) are shown in each box plot

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Genome Medicine

ISSN: 1756-994X

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