Table 3 Variants at genome-wide significance of P value < 5 × 10−8 per adipocytokine/hormone for the base model
SNP | Chr | Position GRCh37 | Alleles ref/tested | NS | MAF | AFR/EAS/EUR/AMR | INFO | beta | SE | P value | Functional class: gene |
|---|---|---|---|---|---|---|---|---|---|---|---|
Adipsin | |||||||||||
 rs199890456 | 6 | 2914945 | C/T | 3402 | 0.2173 | 0.00/0.00/0.00/0.00 | 0.61 | − 0.230 | 0.036 | 2.59E−10 | Intergenic |
 rs201751833 | 2 | 165079139 | T/G | 3713 | 0.2579 | 0.35/0.09/0.15/0.67 | 0.80 | − 0.191 | 0.031 | 5.51E−10 | Intron:AC092684.1 |
 rs1469952 | 2 | 11917519 | G/A | 3713 | 0.2983 | 0.50/0.00/0.56/0.00 | 0.99 | − 0.159 | 0.026 | 1.76E−09 | Utr5:LPIN1 |
 rs115100304 | 2 | 234777140 | C/G | 3713 | 0.0265 | 0.01/0.00/0.00/0.00 | 0.98 | − 0.438 | 0.076 | 8.76E−09 | Intergenic |
 rs34061423 | 14 | 91095586 | C/CT,CAT | 3713 | 0.2480 | NA | 0.92 | − 0.172 | 0.030 | 1.17E−08 | Insertion:TTC7B |
 rs183172404 | 17 | 20247428 | G/A | 3713 | 0.0392 | 0.05/0.00/0.00/0.00 | 0.91 | 0.371 | 0.065 | 1.44E−08 | Intergenic |
 rs539334014 | 11 | 13192725 | G/A,T | 3713 | 0.0234 | 0.00/0.00/0.01/0.00 | 0.60 | − 0.549 | 0.097 | 1.76E−08 | Intergenic |
 rs79750258 | 2 | 64909796 | T/G | 3713 | 0.1776 | 0.05/0.12/0.42/0.11 | 0.61 | − 0.210 | 0.037 | 2.19E−08 | Intron:SERTAD2 |
 rs111651263 | 7 | 93239919 | T/C | 3713 | 0.0560 | 0.04/0.00/0.00/0.00 | 0.99 | − 0.310 | 0.055 | 2.44E−08 | Intron:GNGT1 |
 rs79024755 | 8 | 95715336 | G/T | 3713 | 0.1746 | 0.25/0.00/0.01/0.00 | 0.68 | − 0.195 | 0.035 | 2.64E−08 | Intron:ESRP1 |
 rs113529034 | 7 | 146458922 | T/C | 3713 | 0.2346 | NA | 0.83 | − 0.179 | 0.032 | 2.90E−08 | Intron:CNTNAP2 |
 rs180913374 | 2 | 132099516 | C/T | 3713 | 0.0116 | 0.00/0.00/0.01/0.00 | 0.60 | 0.734 | 0.133 | 3.87E−08 | Intron:PLEKHB2 |
 rs145662005 | 17 | 70334651 | G/C | 3713 | 0.0122 | 0.00/0.00/0.00/0.00 | 0.67 | 0.698 | 0.127 | 4.20E−08 | Intergenic |
Leptin | |||||||||||
 rs28954105 | 7 | 127891616 | G/T | 3745 | 0.1119 | 0.08/0.00/0.00/0.00 | 0.99 | − 0.219 | 0.038 | 6.77E−09 | Intron:LEP |
 rs113453972 | 14 | 64123318 | G/T | 3745 | 0.0538 | 0.05/0.00/0.00/0.00 | 0.99 | − 0.298 | 0.053 | 1.88E−08 | Intergenic |
 rs61258383 | 1 | 88355364 | A/G | 3745 | 0.0531 | 0.29/0.13/0.31/0.25 | 0.95 | 0.300 | 0.054 | 3.55E−08 | Intergenic |
 rs9894577 | 17 | 43223292 | G/A | 3745 | 0.3203 | 0.31/0.23/0.32/0.34 | 0.99 | − 0.140 | 0.026 | 4.41E−08 | Intergenic |
GIP | |||||||||||
 rs12028926 | 1 | 8818438 | C/G | 3751 | 0.0183 | 0.08/1.00/0.27/0.00 | 0.77 | − 0.559 | 0.094 | 3.00E−09 | Intron:RERE |
 rs62266118 | 3 | 115124821 | A/G | 3751 | 0.0211 | 0.06/0.22/0.21/0.00 | 0.75 | − 0.500 | 0.085 | 5.12E−09 | Intergenic |
 rs17437121 | 1 | 23640663 | A/G | 3751 | 0.0219 | 0.03/0.00/0.15/0.10 | 0.81 | 0.499 | 0.090 | 3.46E−08 | Intron:HNRNPR |
 rs17335662 | 11 | 11062119 | C/T | 3751 | 0.0162 | 0.06/0.00/0.22/0.00 | 0.93 | − 0.506 | 0.092 | 3.86E−08 | Intergenic |
 rs182578321 | 9 | 85708499 | C/T | 3751 | 0.0120 | 0.01/0.00/0.00/0.00 | 0.91 | 0.611 | 0.111 | 4.06E−08 | Intergenic |
 rs988623129 | 18 | 44187314 | ATACATATATA CATATATG/A | 3751 | 0.0229 | NA | 0.88 | 0.460 | 0.084 | 4.56E−08 | Deletion:LOXHD1 |
GLP-1 | |||||||||||
 rs1355371392 | 2 | 135283403 | C/A | 1918 | 0.0507 | 0.00/0.00/0.00/0.00 | 0.92 | − 0.476 | 0.080 | 2.47E−09 | Intron:TMEM163 |
 rs73669122 | 9 | 129313248 | C/T | 3783 | 0.1365 | 0.04/0.00/0.00/0.00 | 0.93 | 0.202 | 0.036 | 1.41E−08 | Intergenic |
 rs1450571579 | 1 | 93402186 | C/A | 3783 | 0.0515 | NA | 0.61 | − 0.382 | 0.068 | 2.15E−08 | Intron:FAM69A |
 rs1445210817 | 14 | 64071897 | T/C | 3783 | 0.0155 | 0.00/0.00/0.00/0.00 | 0.48 | − 0.704 | 0.128 | 3.75E−08 | Intron:WDR89 |
 rs372701742 | 8 | 25463403 | T/TA | 3783 | 0.0250 | NA | 0.61 | 0.540 | 0.098 | 4.23E−08 | Intergenic |
PAI-1 | |||||||||||
 rs113421429 | 7 | 100729247 | C/T | 3807 | 0.0978 | 0.18/0.00/0.00/0.00 | 1.00 | − 0.270 | 0.041 | 5.86E−11 | Intron:TRIM56 |
 rs61654751 | 19 | 3436093 | TG/T | 3807 | 0.1056 | 0.13/0.00/0.00/0.00 | 0.95 | − 0.238 | 0.041 | 5.58E−09 | Deletion:NFIC |
 rs2496687 | 6 | 81340947 | C/G | 3807 | 0.7965 | 0.76/1.00/0.91/0.00 | 0.99 | − 0.169 | 0.030 | 2.40E−08 | Intergenic |
IL1-RA | |||||||||||
 rs202017265 | 18 | 13515503 | A/T | 1339 | 0.1543 | 0.21/0.27/0.29/0.17 | 0.71 | − 0.347 | 0.063 | 3.91E−08 | Exon:RP11-53B2.3 |
IL-6 | |||||||||||
 rs72911283 | 18 | 8243353 | T/G | 1263 | 0.0213 | 0.01/0.00/0.07/0.08 | 0.93 | − 0.793 | 0.143 | 3.24E−08 | Intron:PTPRM |
Glucagon | |||||||||||
 rs10809430 | 9 | 11345807 | C/G | 3730 | 0.0138 | 0.00/0.00/0.00/0.00 | 0.92 | 0.590 | 0.106 | 2.91E−08 | Intergenic |
Ghrelin | |||||||||||
 3:49318960 | 3 | 49318960 | C/T | 3777 | 0.0128 | NA | 0.84 | 0.616 | 0.109 | 1.67E−08 | Intron:USP4 |
 rs150921599 | 2 | 72385239 | C/CA | 3777 | 0.1089 | 0.04/0.00/0.00/0.00 | 0.98 | 0.208 | 0.037 | 2.60E−08 | Intergenic |
 rs183921098 | 6 | 159981730 | G/A | 3777 | 0.0101 | 0.01/0.00/0.00/0.00 | 0.88 | 0.663 | 0.119 | 2.97E−08 | Intergenic |
 rs372331930 | 4 | 140418751 | G/GT | 3777 | 0.0343 | 0.06/0.01/0.00/0.02 | 0.89 | 0.365 | 0.067 | 4.42E−08 | Insertion:SETD7 |
Resistin | |||||||||||
 rs3219175 | 19 | 7733855 | G/A | 3754 | 0.0760 | 0.14/0.17/0.01/0.01 | 0.84 | 0.777 | 0.034 | 5.01E−111 | Promotor:RETN |