Fig. 1

Discovery cohort and multiregional trees. Schematic representation of the nine patients from the discovery cohort. Multiregional trees provide evidence of somatic evolution. Text in green and red indicate amplifications and deletions; italics represent predicted drivers, while others are known drivers as determined by Cancer Genome Interpreter. Variants denoted by an asterisk are those that are present in more than one branch of a tree and could not be satisfactorily resolved into a single branch