Table 1 Characteristics of breast cancer patients. IQR interquartile range
From: Germline breast cancer susceptibility genes, tumor characteristics, and survival
| Â | N (%) |
|---|---|
Demographics | |
 Study | |
  SGBCC | 4529 (51%) |
  MyBrCa | 3761 (42%) |
  KOHBRA | 562 (6%) |
 Case type | |
  Incident | 5229 (59%) |
  Prevalent | 3587 (41%) |
  Unknown | 36 (0%) |
 Median age at diagnosis (IQR) | 51 (44–59) |
  Unknown | 30 |
 Ethnicity | |
  Chinese | 6265 (71%) |
  Malay | 1213 (14%) |
  Indian | 707 (8%) |
  Korean | 562 (6%) |
  Others | 86 (1%) |
  Unknown | 19 (0%) |
 Family history | |
  No | 6968 (79%) |
  Yes | 1220 (14%) |
  Unknown | 664 (8%) |
Tumor characteristics | |
 Tumor behavior | |
  In situ | 1028 (12%) |
  Invasive | 7478 (84%) |
  Unknown | 346 (4%) |
 Stage | |
  0 | 759 (9%) |
  I | 2244 (25%) |
  II | 2746 (31%) |
  III | 1123 (13%) |
  IV | 270 (3%) |
  Unknown | 1710 (19%) |
 Nodal status | |
  Negative | 4765 (54%) |
  Positive | 2889 (33%) |
  Unknown | 1198 (14%) |
 Tumor size, cm | |
  ≤2 | 1171 (13%) |
  2–5 | 1837 (21%) |
  >5 | 3916 (44%) |
  Unknown | 1928 (22%) |
 Grade | |
  Well-differentiated | 1029 (12%) |
  Moderately differentiated | 3284 (37%) |
  Poorly differentiated | 3038 (34%) |
  Unknown | 1501 (17%) |
 Estrogen receptor status | |
  Positive | 5542 (63%) |
  Negative | 2242 (25%) |
  Unknown | 1068 (12%) |
 Progesterone receptor status | |
  Positive | 4722 (53%) |
  Negative | 2820 (32%) |
  Unknown | 1310 (15%) |
 HER2 receptor status | |
  Positive | 1894 (21%) |
  Negative | 4645 (52%) |
  Unknown | 2313 (26%) |
 Proxy subtype | |
  Luminal A | 2448 (28%) |
  Luminal B [HER2−] | 837 (9%) |
  Luminal B [HER2+] | 1033 (12%) |
  HER2-overexpressed | 757 (9%) |
  Triple-negative | 914 (10%) |
  Unknown | 2863 (32%) |
Protein-truncating variants (PTVs) | |
 PTV 34 genes | |
  Non-carrier | 7873 (89%) |
  Carrier | 979 (11%) |
 PTV 9 genes |  |
  Non-carrier | 8162 (92%) |
  Carrier | 690 (8%) |
 PTV 25 genes |  |
  Non-carrier | 8524 (96%) |
  Carrier | 328 (4%) |