Fig. 2

CanDI enables a global analysis of conditional essentiality in cancer. A Average gene essentiality for KRAS and EGFR in groups of NSCLC cell lines stratified by KRAS mutation status. N = 61 for KRAS-wildtype shown in blue. N = 33 for KRAS-mutant shown in blue. Gene essentiality is the average gene effect (CERES score) across all cell lines for the given group. B Average gene essentiality for KRAS and EGFR in groups of NSCLC cell lines stratified by EGFR mutation status. N = 77 for EGFR-wildtype shown in blue, N = 17 for EGFR-mutant shown in blue. Gene essentiality is the average gene effect (CERES score) of all cell lines within a given group. C P values from chi-square tests of gene essentiality and nonsense mutations. D P values from chi-square tests of gene essentiality and missense mutations. E A scatter plot showing effect size of the change in gene essentiality with select missense mutations and the − Log10(P value) of each essentiality/mutation pair. F A scatter plot showing effect size of the change in gene essentiality with select nonsense mutations and the − Log10(P value) of each essentiality/mutation pair. G A scatter plot showing effect size of the change in gene essentiality with all mutations and the − Log10(P value) of each essentiality/mutation pair