Fig. 5
From: Constructing germline research cohorts from the discarded reads of clinical tumor sequences
PRS associations with cancer types. a Each row corresponds to a different tested PRS, and each column shows a different tumor/cancer type. Bars (x-axis) show the significance of the PRS-cancer type association on the -log10 p-value scale (higher = more significant). Bonferroni significant associations are shown in darker shades. Note that the significance of the PRS depends on both prediction accuracy as well as target sample size and should not be directly compared across cancer types. b Odds ratio (x-axis) of the top risk PRS decile associated with the corresponding cancer type shown for each cancer type (y-axis). The shaded bar shows the standard error of the estimate from a logistic regression