Fig. 3
From: Beyondcell: targeting cancer therapeutic heterogeneity in single-cell RNA-seq data
Beyondcell characterises single-cell variability in drug response in pan-cancer cell line data. a Heatmap depicting both the cluster and cancer-specific drugs with a heterogeneous sensitivity pattern found in Kinker et al. [18]. The heatmap has been ordered according to the detected therapeutic clusters, while drug signatures have been clustered based on their BCS. Furthermore, the distinct cancer types have been colour coded. Only drugs with a mechanism-of-action (MoA) annotation are shown. b The heatmap depicts the correlation score between each BCS and the described RHPs. Here, we found EGFR inhibitors to be highly correlated with the Epithelial Senescence, EMT III and p53-dependent senescence programs, while tyrosine kinase inhibitors or topoisomerase inhibitors were anticorrelated. Further details are available in Additional file 1: Supplementary Methods and Figures