Fig. 3From: ClinGen Variant Curation Interface: a variant classification platform for the application of evidence criteria from ACMG/AMP guidelinesVCI platform components overview including schema and serverless architecture. The platform is web-browser based and uses AWS cloud services. An External Resources Manager retrieves population, predictive, functional, and other variant and gene-level data from external sources (Table 1) via APIs. In addition, the user can add in curated evidence, evaluate against ACMG/AMP guidelines, and save the classification for review and approval. The approved classifications are then submitted to the ClinGen Evidence Repository. All data are saved in a database via microservices and can be accessed via queries. The Amazon Cloud Services provide the microservices to store and retrieve data adopting a Serverless Architecture utilizing the following components and services: Amplify, Cognito, API Gateway, Lambda, DynamoDB, S3, and the user-facing web interface is created using React JavaScript LibraryBack to article page