Fig. 5

Correlations between L-scores and drug sensitivity in lung cancer cell lines. A, B The L-score is negatively correlated with cell sensitivity to EGFR inhibitors, erlotinib (A) and gefitinib (B) in the dataset GSE32989 [42]. C The L-score is negatively correlated with cell sensitivity to erlotinib in the dataset GDSC [35]. The association is not significant in lung adenocarcinoma cell lines due to the low sample number with sensitivity data (red) but is significant in all lung cancer cell lines (gray). D The L-score is positively correlated with cell sensitivity to AZD7762 in the dataset GDSC [35]. Drug sensitivity is represented as -ln(IC50 + 1) in GSE32989 [42] and as -AUC (area under the curve) in GDSC [35]. SCC Spearman correlation coefficient