Microbiota of the prostate tumor environment investigated by whole-transcriptome profiling

Table 4 Validation of species identified as differentially abundant between malignant and benign tissue samples in the discovery cohort

Organism name	Base mean	Log₂ fold change	lfcSE	Wald statistic	p value	p adj
Malignant vs. benign tissue (validation cohort)
Shewanella	10.97	1.49	0.32	4.64	3.33e−06	1.6e−05*
Bacteroides fragilis	276.86	−0.08	0.24	−0.35	0.7253	0.7253
Saimiriine betaherpesvirus	17.75	−0.58	0.37	−1.54	0.1214	0.1517
Staphylococcus saprophyticus	180.95	−1.67	0.68	−2.44	0.0145	0.0242*
Vibrio parahaemolyticus	60.13	−0.62	0.19	−3.30	0.0009	0.0024*

Note: Species identified as differentially abundant in the discovery cohort were tested for their differential abundance in the validation cohort. Significance was determined at an adjusted p value less than 0.05 (marked by asterisk). Base mean, mean of the normalized count across all samples. lfcSE standard error of the log₂ fold change, p-adj Benjamini-Hochberg adjusted p value

ISSN: 1756-994X