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Fig. 8 | Genome Medicine

Fig. 8

From: Genome-scale CRISPR screens identify host factors that promote human coronavirus infection

Fig. 8

Inhibitor, phospholipidosis, and cytotoxicity measurements of anti-SARS-CoV-2 host factors tested in human SAEC. A TCID50 of SARS-CoV-2 in SAEC-hACE2 cells compared to DMSO control. B TCID50 of OC43 in SAEC cells compared to DMSO control. CH Phospholipidosis was measured in SAEC-hACE2 cells across several drug concentrations after 3 days of treatment and normalized to 5 μM of amiodarone (AMD) as a positive lipidosis control. IN Cytotoxicity was measured by LDH release at the same concentrations. Dashed red lines in DH and JN coincide with inhibitor concentrations used in A and B. Error bars denote standard errors of mean and P values were determined using one-way ANOVA (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001)

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