Fig. 8
From: Genome-scale CRISPR screens identify host factors that promote human coronavirus infection
Inhibitor, phospholipidosis, and cytotoxicity measurements of anti-SARS-CoV-2 host factors tested in human SAEC. A TCID50 of SARS-CoV-2 in SAEC-hACE2 cells compared to DMSO control. B TCID50 of OC43 in SAEC cells compared to DMSO control. C–H Phospholipidosis was measured in SAEC-hACE2 cells across several drug concentrations after 3 days of treatment and normalized to 5 μM of amiodarone (AMD) as a positive lipidosis control. I–N Cytotoxicity was measured by LDH release at the same concentrations. Dashed red lines in D–H and J–N coincide with inhibitor concentrations used in A and B. Error bars denote standard errors of mean and P values were determined using one-way ANOVA (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001)