Table 2 Summarized performance of gene signatures in bacterial and viral classification

TS1

0.547 [0.445–0.658]

0.825 [0.74–0.887]

0.592 [0.473–0.702]

7 [5–10]

0.826 [0.729–0.892]

0.872 [0.813–0.914]

0.867 [0.806–0.911]

44 [25–79]

HL2

0.778 [0.667–0.857]

0.812 [0.723–0.877]

0.862 [0.787–0.913]

27 [14–52]

0.861 [0.803–0.903]

0.81 [0.74–0.865]

0.905 [0.84–0.945]

41 [21–80]

LC2

0.764 [0.652–0.843]

0.873 [0.786–0.928]

0.799 [0.706–0.868]

27 [14–54]

0.641 [0.55–0.737]

0.808 [0.709–0.88]

0.7 [0.558–0.812]

10 [6–17]

XW2

0.690 [0.608–0.763]

0.741 [0.63–0.828]

0.803 [0.711–0.871]

12 [7–19]

0.851 [0.775–0.894]

0.815 [0.747–0.867]

0.874 [0.824–0.911]

30 [17–53]

GS3

0.796 [0.655–0.910]

0.836 [0.75–0.897]

0.92 [0.852–0.958]

58 [23–147]

0.843 [0.767–0.901]

0.812 [0.735–0.871]

0.876 [0.813–0.92]

31 [15–62]

LS3

0.764 [0.692–0.838]

0.778 [0.718–0.829]

0.792 [0.705–0.858]

13 [8–21]

0.831 [0.782–0.876]

0.804 [0.752–0.848]

0.849 [0.774–0.903]

23 [13–41]

SB4

0.776 [0.662-0.876]

0.83 [0.743-0.892]

0.792 [0.707–0.858]

19 [10–36]

0.868 [0.817–0.914]

0.807 [0.76–0.846]

0.896 [0.851–0.929]

36 [22–60]

SK7

0.863 [0.812–0.922]

0.861 [0.813–0.898]

0.88 [0.821–0.921]

45 [24–87]

0.901 [0.849–0.936]

0.866 [0.822–0.9]

0.883 [0.829–0.922]

49 [26–91]

SB8

0.835 [0.734–0.914]

0.86 [0.759–0.923]

0.859 [0.778–0.913]

37 [17–83]

0.884 [0.836–0.924]

0.832 [0.788–0.869]

0.884 [0.842–0.915]

38 [23–63]

RC10

0.849 [0.708–0.931]

0.886 [0.817–0.931]

0.909 [0.817–0.958]

78 [27–227]

0.922 [0.871–0.955]

0.892 [0.85–0.923]

0.901 [0.841–0.939]

75 [35–161]

SN10

0.854 [0.758–0.918]

0.868 [0.825–0.901]

0.867 [0.786–0.921]

43 [20–90]

0.897 [0.846–0.937]

0.837 [0.787–0.878]

0.915 [0.872–0.944]

55 [30–103]

SR10

0.844 [0.759–0.909]

0.843 [0.779–0.891]

0.89 [0.839–0.927]

43 [23–82]

0.915 [0.865–0.950]

0.902 [0.86–0.932]

0.903 [0.859–0.934]

85 [42–171]

AK11

0.794 [0.708–0.879]

0.794 [0.703–0.862]

0.875 [0.81–0.92]

27 [14–51]

0.887 [0.826–0.923]

0.849 [0.784–0.897]

0.862 [0.813–0.9]

35 [19–66]

BF11

0.812 [0.742–0.866]

0.85 [0.794–0.892]

0.815 [0.746–0.869]

25 [13–48]

0.801 [0.748–0.843]

0.816 [0.768–0.856]

0.768 [0.706–0.82]

15 [10–22]

NC19

0.832 [0.753–0.897]

0.864 [0.792–0.914]

0.839 [0.784–0.882]

33 [18–61]

0.885 [0.825–0.921]

0.86 [0.819–0.892]

0.858 [0.805-0.899]

37 [21-66]

SL20

0.850 [0.748–0.907]

0.84 [0.78–0.886]

0.88 [0.83–0.917]

38 [18–81]

0.915 [0.868–0.948]

0.899 [0.858–0.929]

0.889 [0.842–0.924]

71 [37–136]

MW23

0.826 [0.732–0.889]

0.874 [0.82–0.914]

0.829 [0.738–0.893]

34 [17–66]

0.894 [0.838–0.933]

0.875 [0.826–0.911]

0.885 [0.839–0.919]

54 [28–105]

ZG25

0.817 [0.716–0.889]

0.843 [0.767–0.898]

0.849 [0.785–0.896]

30 [15–60]

0.882 [0.815–0.926]

0.86 [0.792–0.909]

0.892 [0.849–0.924]

51 [27–95]

MS29

0.873 [0.766–0.938]

0.912 [0.855–0.948]

0.883 [0.796–0.936]

78 [30–206]

0.894 [0.826–0.937]

0.826 [0.754–0.881]

0.885 [0.827–0.925]

37 [19–71]

PT29

0.810 [0.716–0.889]

0.846 [0.769–0.901]

0.837 [0.777–0.884]

28 [15–55]

0.873 [0.821–0.911]

0.827 [0.773–0.87]

0.845 [0.797–0.883]

26 [15–44]

RC31

0.842 [0.755–0.903]

0.868 [0.804–0.913]

0.849 [0.764–0.907]

37 [17–79]

0.891 [0.836–0.927]

0.857 [0.816–0.89]

0.871 [0.815–0.912]

40 [24–67]

HS33

0.854 [0.771–0.913]

0.878 [0.812–0.923]

0.864 [0.796–0.912]

46 [21–98]

0.891 [0.820–0.934]

0.861 [0.796–0.908]

0.893 [0.838–0.931]

52 [26–103]

HL34

0.814 [0.690–0.895]

0.833 [0.752–0.892]

0.871 [0.809–0.915]

34 [17-67]

0.898 [0.831–0.942]

0.871 [0.811–0.915]

0.906 [0.858–0.939]

65 [33–128]

ZG48

0.847 [0.760–0.914]

0.912 [0.841–0.953]

0.883 [0.8–0.935]

78 [32–194]

0.876 [0.799–0.928]

0.846 [0.79–0.889]

0.886 [0.84–0.919]

43 [23–77]

MR59

0.829 [0.724–0.904]

0.909 [0.843–0.949]

0.846 [0.76–0.905]

55 [24–127]

0.864 [0.797–0.918]

0.816 [0.746–0.87]

0.881 [0.833–0.916]

33 [18–61]

TW96

0.844 [0.757–0.921]

0.908 [0.83–0.952]

0.91 [0.843–0.95]

99 [36–271]

0.871 [0.808–0.935]

0.923 [0.867–0.957]

0.898 [0.836–0.938]

106 [39–284]

MW139

0.834 [0.750–0.908]

0.906 [0.835–0.949]

0.869 [0.788–0.922]

64 [28–146]

0.871 [0.808–0.923]

0.887 [0.841–0.921]

0.884 [0.808–0.932]

60 [26–138]

AK398

0.886 [0.820–0.951]

0.939 [0.887–0.968]

0.923 [0.868–0.956]

184 [61–553]

0.896 [0.850–0.946]

0.912 [0.867–0.942]

0.932 [0.866–0.966]

141 [51–392]

All

0.905 [0.842–0.957]

0.927 [0.881–0.956]

0.927 [0.875–0.959]

162 [65–401]

0.933 [0.898–0.965]

0.934 [0.9–0.957]

0.92 [0.872–0.951]

164 [73–369]