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Table 2 Summarized performance of gene signatures in bacterial and viral classification

From: Systematic comparison of published host gene expression signatures for bacterial/viral discrimination

Signature Bacterial vs. non-bacterial Viral vs. non-viral
Weighted Mean AUC (95% CI) Sensitivity (95% CI) Specificity (95% CI) DOR (95% CI) Weighted Mean AUC (95% CI) Sensitivity (95% CI) Specificity (95% CI) DOR (95% CI)
TS1 0.547 [0.445–0.658] 0.825 [0.74–0.887] 0.592 [0.473–0.702] 7 [5–10] 0.826 [0.729–0.892] 0.872 [0.813–0.914] 0.867 [0.806–0.911] 44 [25–79]
HL2 0.778 [0.667–0.857] 0.812 [0.723–0.877] 0.862 [0.787–0.913] 27 [14–52] 0.861 [0.803–0.903] 0.81 [0.74–0.865] 0.905 [0.84–0.945] 41 [21–80]
LC2 0.764 [0.652–0.843] 0.873 [0.786–0.928] 0.799 [0.706–0.868] 27 [14–54] 0.641 [0.55–0.737] 0.808 [0.709–0.88] 0.7 [0.558–0.812] 10 [6–17]
XW2 0.690 [0.608–0.763] 0.741 [0.63–0.828] 0.803 [0.711–0.871] 12 [7–19] 0.851 [0.775–0.894] 0.815 [0.747–0.867] 0.874 [0.824–0.911] 30 [17–53]
GS3 0.796 [0.655–0.910] 0.836 [0.75–0.897] 0.92 [0.852–0.958] 58 [23–147] 0.843 [0.767–0.901] 0.812 [0.735–0.871] 0.876 [0.813–0.92] 31 [15–62]
LS3 0.764 [0.692–0.838] 0.778 [0.718–0.829] 0.792 [0.705–0.858] 13 [8–21] 0.831 [0.782–0.876] 0.804 [0.752–0.848] 0.849 [0.774–0.903] 23 [13–41]
SB4 0.776 [0.662-0.876] 0.83 [0.743-0.892] 0.792 [0.707–0.858] 19 [10–36] 0.868 [0.817–0.914] 0.807 [0.76–0.846] 0.896 [0.851–0.929] 36 [22–60]
SK7 0.863 [0.812–0.922] 0.861 [0.813–0.898] 0.88 [0.821–0.921] 45 [24–87] 0.901 [0.849–0.936] 0.866 [0.822–0.9] 0.883 [0.829–0.922] 49 [26–91]
SB8 0.835 [0.734–0.914] 0.86 [0.759–0.923] 0.859 [0.778–0.913] 37 [17–83] 0.884 [0.836–0.924] 0.832 [0.788–0.869] 0.884 [0.842–0.915] 38 [23–63]
RC10 0.849 [0.708–0.931] 0.886 [0.817–0.931] 0.909 [0.817–0.958] 78 [27–227] 0.922 [0.871–0.955] 0.892 [0.85–0.923] 0.901 [0.841–0.939] 75 [35–161]
SN10 0.854 [0.758–0.918] 0.868 [0.825–0.901] 0.867 [0.786–0.921] 43 [20–90] 0.897 [0.846–0.937] 0.837 [0.787–0.878] 0.915 [0.872–0.944] 55 [30–103]
SR10 0.844 [0.759–0.909] 0.843 [0.779–0.891] 0.89 [0.839–0.927] 43 [23–82] 0.915 [0.865–0.950] 0.902 [0.86–0.932] 0.903 [0.859–0.934] 85 [42–171]
AK11 0.794 [0.708–0.879] 0.794 [0.703–0.862] 0.875 [0.81–0.92] 27 [14–51] 0.887 [0.826–0.923] 0.849 [0.784–0.897] 0.862 [0.813–0.9] 35 [19–66]
BF11 0.812 [0.742–0.866] 0.85 [0.794–0.892] 0.815 [0.746–0.869] 25 [13–48] 0.801 [0.748–0.843] 0.816 [0.768–0.856] 0.768 [0.706–0.82] 15 [10–22]
NC19 0.832 [0.753–0.897] 0.864 [0.792–0.914] 0.839 [0.784–0.882] 33 [18–61] 0.885 [0.825–0.921] 0.86 [0.819–0.892] 0.858 [0.805-0.899] 37 [21-66]
SL20 0.850 [0.748–0.907] 0.84 [0.78–0.886] 0.88 [0.83–0.917] 38 [18–81] 0.915 [0.868–0.948] 0.899 [0.858–0.929] 0.889 [0.842–0.924] 71 [37–136]
MW23 0.826 [0.732–0.889] 0.874 [0.82–0.914] 0.829 [0.738–0.893] 34 [17–66] 0.894 [0.838–0.933] 0.875 [0.826–0.911] 0.885 [0.839–0.919] 54 [28–105]
ZG25 0.817 [0.716–0.889] 0.843 [0.767–0.898] 0.849 [0.785–0.896] 30 [15–60] 0.882 [0.815–0.926] 0.86 [0.792–0.909] 0.892 [0.849–0.924] 51 [27–95]
MS29 0.873 [0.766–0.938] 0.912 [0.855–0.948] 0.883 [0.796–0.936] 78 [30–206] 0.894 [0.826–0.937] 0.826 [0.754–0.881] 0.885 [0.827–0.925] 37 [19–71]
PT29 0.810 [0.716–0.889] 0.846 [0.769–0.901] 0.837 [0.777–0.884] 28 [15–55] 0.873 [0.821–0.911] 0.827 [0.773–0.87] 0.845 [0.797–0.883] 26 [15–44]
RC31 0.842 [0.755–0.903] 0.868 [0.804–0.913] 0.849 [0.764–0.907] 37 [17–79] 0.891 [0.836–0.927] 0.857 [0.816–0.89] 0.871 [0.815–0.912] 40 [24–67]
HS33 0.854 [0.771–0.913] 0.878 [0.812–0.923] 0.864 [0.796–0.912] 46 [21–98] 0.891 [0.820–0.934] 0.861 [0.796–0.908] 0.893 [0.838–0.931] 52 [26–103]
HL34 0.814 [0.690–0.895] 0.833 [0.752–0.892] 0.871 [0.809–0.915] 34 [17-67] 0.898 [0.831–0.942] 0.871 [0.811–0.915] 0.906 [0.858–0.939] 65 [33–128]
ZG48 0.847 [0.760–0.914] 0.912 [0.841–0.953] 0.883 [0.8–0.935] 78 [32–194] 0.876 [0.799–0.928] 0.846 [0.79–0.889] 0.886 [0.84–0.919] 43 [23–77]
MR59 0.829 [0.724–0.904] 0.909 [0.843–0.949] 0.846 [0.76–0.905] 55 [24–127] 0.864 [0.797–0.918] 0.816 [0.746–0.87] 0.881 [0.833–0.916] 33 [18–61]
TW96 0.844 [0.757–0.921] 0.908 [0.83–0.952] 0.91 [0.843–0.95] 99 [36–271] 0.871 [0.808–0.935] 0.923 [0.867–0.957] 0.898 [0.836–0.938] 106 [39–284]
MW139 0.834 [0.750–0.908] 0.906 [0.835–0.949] 0.869 [0.788–0.922] 64 [28–146] 0.871 [0.808–0.923] 0.887 [0.841–0.921] 0.884 [0.808–0.932] 60 [26–138]
AK398 0.886 [0.820–0.951] 0.939 [0.887–0.968] 0.923 [0.868–0.956] 184 [61–553] 0.896 [0.850–0.946] 0.912 [0.867–0.942] 0.932 [0.866–0.966] 141 [51–392]
All 0.905 [0.842–0.957] 0.927 [0.881–0.956] 0.927 [0.875–0.959] 162 [65–401] 0.933 [0.898–0.965] 0.934 [0.9–0.957] 0.92 [0.872–0.951] 164 [73–369]
  1. Weighted mean AUC, sensitivity, specificity, and diagnostic odds ratio (DOR) for each host gene expression signature are presented. Values were weighted based on the number of subjects in the validation dataset. Sensitivity, specificity, and DOR values and their confidence intervals were calculated using hierarchical summary ROC modeling.