Fig. 2
Impact of alterations in RAD21 and HGF on telomeric content in FMI dataset. A A plot showing genes where alterations were associated with significant differences in telomeric content within a disease group. Per gene and tumor type, we compared the frequency of alterations within samples in the top quartile of telomeric content to the frequency of alterations in the bottom quartile. The size of each circle represents the -log10 P value and its position along the x-axis represents the log2 odds ratio. Genes with a signal in 3 unique disease groups are shown in slate blue, while those with signals in two unique disease groups are colored in mint green. P values were adjusted for multiple hypothesis testing using Bonferroni’s correction. OR, odds ratio. B Bar plot depicting the prevalence of RAD21 alterations within the top 5 disease ontologies. C Boxplots showing the impact of alterations within RAD21 and HGF on the telomeric content of samples in the FMI dataset. Diseases were selected based on the results shown in A. WT, wild-type; Alt, altered. *** signifies p<0.001 and **** p<0.0001