Fig. 5

Mutual exclusivity of telomere-maintenance genes and impact of co-occurrence when it rarely occurs. A Tile plot showing the distribution of alterations in ATRX, DAXX, TERC, TERTp, RAD21, and HGF within 20,444 samples in the FMI dataset. Plot depicts samples with at least one alteration in these genes. Altered samples are shown in orange and non-altered samples are shown as white. The impact of multiple alterations within these genes on telomeric content is shown for prostate acinar adenocarcinoma in B and gliomas in C. Within each group, the symbol (+) means altered and the symbol (−) means non-altered. * denotes p<0.05, ** p<0.01, *** p<0.001, and **** p<0.0001