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Fig. 5 | Genome Medicine

Fig. 5

From: Integration of genetic colocalizations with physiological and pharmacological perturbations identifies cardiometabolic disease genes

Fig. 5

Genes prioritized through colocalization analysis respond to metabolic perturbations. a Candidate causal genes with differential expression (DE) under five metabolic perturbations (FDR < 5%). b Protein-protein interaction (PPI) network interactions in perturbation conditions between uniquely colocalized genes and seven known monogenic insulin resistance (IR) or T2D genes. Colocalized genes in blue nodes interact directly with the monogenic IR/T2D genes in red nodes; colocalized genes in yellow nodes interact via one intermediary gene. All genes in the central gray circle interact with multiple monogenic IR/T2D genes on the periphery, and genes closer to the center interact with more of the monogenic IR/T2D genes. To simplify visualization, not all direct links are depicted for genes with multiple interactions

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Genome Medicine

ISSN: 1756-994X

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