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Fig. 1 | Genome Medicine

Fig. 1

From: Interaction of bacterial genera associated with therapeutic response to immune checkpoint PD-1 blockade in a United States cohort

Fig. 1

Responders to immunotherapy have a different microbial community structure and metatranscriptome than non-responders at baseline. A Box plot of weighted UniFrac second PCoA of responder (n = 22) and non-responder (n = 43) participants showing the difference between the two groups. PERMANOVA P = 0.03, gls P = 0.004 (see Additional file 7: Figure 1A for full PCoA). B Log2 fold change (log2FC) plot of significantly (FDR-P < 0.05) enriched amplicon sequence variants (ASVs) in responder versus non-responder subjects. Filled circles located above y = 0 indicate enrichment in responders, and those below indicate enrichment in non-responders. Only significant ASVs for the top 20 enriched genera in each direction are shown. See Additional file 7: Figure S1B for the full list. C PCA showing the different clustering of responders (n = 6) versus non-responders (n = 14) metatranscriptomes. gls P = 0.032

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Genome Medicine

ISSN: 1756-994X

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