Skip to main content

Table 1 Overview of the study cohort characteristics. Patient characteristics stratified by response status for all 65 patients from Moffitt Cancer Center receiving ICI for stage III/IV non-small cell lung cancer. Values are represented in number and percentage or mean and standard deviation. Responder (R) vs. non-responder (NR) study cohort characteristics

From: Interaction of bacterial genera associated with therapeutic response to immune checkpoint PD-1 blockade in a United States cohort

  Total % or SD R % or SD NR % or SD
Number of patients (total = 65) 65 100% 18 28% 47 72%
Liquid Dental Transport Medium (LDTM) stool 16 25% 4 22% 6 13%
Gender
 Male 33 51% 8 44% 25 53%
 Female 32 49% 10 56% 22 47%
Race
 White 58 89% 17 94% 41 87%
 Black or African American 6 9% 1 6% 5 11%
 Others 1 2% 0 0% 1 2%
Antibiotics taken 2 months prior to treatment 18 28% 5 28% 13 28%
Pro/prebiotics taken 2 months prior to treatment 10 15% 3 17% 7 15%
NSCLC stage at ICI treatment start
 IIIA 3 5% 1 6% 2 4%
 IIIB 1 2% 0 0% 1 2%
 IV 61 94% 17 94% 44 94%
Type of immunotherapy given
 Anti-PD-1 43 66% 15 83% 29 60%
 Anti-PD-L1 19 29% 3 17% 16 34%
 Anti-PD-1, CTLA-4 2 3% 0 0% 2 4%
Tumor biopsy PDL-1 gene mutation test result
 Positive 35 54% 12 67% 23 49%
 Negative 21 32% 4 22% 17 36%
 Not tested 9 14% 2 11% 7 15%
Mean PLD-1 percent (if positive) 57% ± 35% 65% ± 34% 53% ± 36%
Adverse event related to treatment 53 82% 14 78% 39 83%
Prior/concurrent treatment
 Chemotherapy use prior to ICI 37 57% 8 44% 29 62%
 Thoracic radiation prior to ICI 19 29% 5 28% 14 30%
 Other radiation prior to ICI 24 37% 6 33% 18 38%
 Targeted therapy prior to ICI 14 22% 2 11% 12 26%
 Immunotherapy prior to ICI 3 5% 1 6% 2 4%
 Concurrent chemotherapy 37 57% 11 61% 26 55%
 Concurrent thoracic radiation 8 12% 1 6% 7 15%
 Concurrent other radiation 14 22% 3 17% 11 23%
Baseline smoking history (current or former) 60 92% 17 94% 43 91%
Prior presence of colitis 8 12% 2 11% 6 13%
Prior presence of H. pylori infection 2 3% 1 6% 1 2%
Durable response
 Responder 22 34% 18 100% 0 0%
 Non-responder 43 66% 0 0% 47 100%
Mean PFS 292.7 ± 231.3 514.7 ± 209.3 207.7 ± 177.7
Mean age at presentation 66.2 ± 8.9 64.7 ± 7.0 66 ± 9.7
Mean BMI 26.1 ± 6.3 26.0 ± 3.8 26.1 ± 7.0