From: Rapid molecular diagnostics of tuberculosis resistance by targeted stool sequencing
Cohort characteristics | Eswatini cohort N (%) | German cohort N (%) | |
---|---|---|---|
Total number | Â | 66 | 21 |
Sex | Female | 39 (59) | 2 (10) |
Male | 27 (41) | 19 (90) | |
Age (years) | Median (IQR) | 31 (22–36) | 30 (22–39) |
Age | 0 to 18 | 10 (15) | 0 |
19 and above | 56 (85) | 21 (100) | |
Tuberculosis disease classification | Confirmed | 63 (96) | 21 (100) |
Probable | 3 (4) | 0 | |
HIV status | Positive | 44 (67) | 0 |
Negative | 22 (33) | 21 (100) | |
CD4(cells/ml) | Median cells/ml (IQR) | 248 (121–346)a | NA |
BMI | Median (IQR) | 20 (18–23)b | 21 (19–24) |
Sputum Xpert MTB/RIF Ultra | M. tuberculosis complex: Detected | 55 (83) | 16 (76) |
M. tuberculosis complex: Trace | 0 | 2 (10) | |
M. tuberculosis complex: Not detected | 6 (9) | 1 (5) | |
NA | 5 (8) | 2 (10) | |
Xpert rifampicin resistance | Detected | 3 (6) | 8 (50) |
Not detected | 47 (86) | 8 (50) | |
NA | 5 (8) | NA | |
Sputum culture result | Positive | 48 (73) | 21 (100) |
Negative | 5 (8) | 0 | |
NA | 13 (19) | 0 | |
Stool PCR qualitative result | M. tuberculosis complex | 56 (85) | 16 (76) |
Detected | Â | Â | |
M. tuberculosis complex | 10 (15) | 5 (24) | |
Not Detected | Â | Â | |
Stool PCR fg/μl M. tuberculosis complex DNA |  > 100 | 10 (18) | 2 (13) |
1 to 100 | 25 (45) | 7 (44) | |
 < 1 | 21 (37) | 7 (44) |