Fig. 4

RNA sequencing samples stratified by consensus clustering. A Three stable expression subtypes were identified from the set of 78 RNA sequencing samples (on the x-axis beneath the heatmap). The characteristic traits for each of the expression subtypes were determined by the expression levels of marker genes (on the y-axis to the right of the heatmap). The labels for the marker gene sets are noted on the left of the heatmap. In addition, there are annotation ribbons on top of the heatmap for the clinical phenotype features (tumour grade, stage, gender, age, smoking, and BCG response) and colour coding for the expression subtypes identified in this study (“BCPP_Class”) and the subtype as assigned by the UROMOL classifier (“UROMOL_NMIBC”). B Sankey plot showing the sample level correspondence between the BCPP RNA classification and the UROMOL 2021 RNA classification for the same cohort of 78 RNA sequencing samples