Fig. 1

Whole genome somatic mutation burden for the Creaney et al cohort. A Clinical features of the 58 mesothelioma samples that underwent WGS. B Somatic variant load per megabase from single (SNV), dinucleotide (DNP) and trinucleotide (TNP) substitutions and short insertion and deletion (indels) variants. C Counts of structural rearrangements identified in each sample categorized by SV type. D Proportion of each tumour genome with copy number alteration (CNA). Evidence of whole genome duplication for 17 samples with > 90% of genome with CNA and > 70% of genome copy number 3-6 and a ploidy of > 2.7. E Kaplan-Meier curve showing overall survival was reduced in patients with evidence of whole genome duplication. F Density of mutations within the genomes of the 58 mesothelioma samples. Each plot is ordered by chromosome (x-axis). Plots show from top to bottom: genomic density of SNV and indel mutations; genomic density of SV breakpoints; frequency of amplifications (red) and deletions (green) within samples