Fig. 3
From: Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women
WID-Breast29 score in triple negative breast cancer (TNBC) and adjacent normal tissues. a The WID-Breast29 score is based on 37 CpGs from 29 genes and b was significantly greater in normal breast tissue surrounding TNBC (n = 14) when compared to normal tissue from cancer-free women (n = 14); significance was assessed with the t-test. c The WID-Breast29 score also increased significantly when transitioning from normal surrounding tissue to TNBC (n = 14) or d ER+ve/PR+ve breast cancer (n = 31); gold lines indicate increasing and blue decreasing values from surround normal to the cancer tissue in individual breast cancer patients; significance was assessed with the paired-sample t-test. e The WID-Breast29 score was also significantly associated with patient survival outcome in 257 TCGA breast cancer samples (after adjusting for covariates); significance was assessed by z-tests on the Wald statistics after fitting a multivariate Cox proportional hazards model