Table 3 Prediction accuracy of the trans-ancestry T2D PRS in four Black cohorts
Cohort | Liability R2 | Covariates-adjusted AUC | OR per SD (95% CI) | Top 2% PRS | |||||
|---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | P value | Sensitivity | Specificity | Adjusted PPV* | Adjusted NPV* | ||||
REGARDS | 4.6% | 0.61 | 1.70 (1.58, 1.84) | 3.04 (2.15, 4.31) | 3.87E−10 | 0.04 | 0.99 | 0.30 | 0.88 |
GenHAT | 3.6% | 0.61 | 1.85 (1.70, 2.01) | 2.70 (1.74, 4.18) | 8.44E−06 | 0.03 | 0.99 | 0.26 | 0.88 |
HyperGen | 6.2% | 0.62 | 1.75 (1.52, 2.02) | 3.37 (1.69, 6.69) | 5.37E−04 | 0.05 | 0.99 | 0.34 | 0.88 |
Warfarin | 1.5% | 0.57 | 1.37 (1.13, 1.65) | 2.70 (0.80, 9.09) | 1.09E−01 | 0.01 | 0.98 | 0.07 | 0.87 |