Skip to main content
Fig. 2 | Genome Medicine

Fig. 2

From: Single-cell multimodal analysis identifies common regulatory programs in synovial fibroblasts of rheumatoid arthritis patients and modeled TNF-driven arthritis

Fig. 2

Structural remodeling of the synovial mesenchyme in the hTNFtg arthritic joint. A UMAP representation of SFs across the three different samples (WT, hTNFtg/4 weeks, and hTNFtg/8 weeks as indicated). The cells are colored by cluster identities, and the marked areas highlight the structural dynamic changes of the intermediate and lining subpopulations in RA evolution/during disease progression. B Stacked bar charts showing the relative abundances (%) of clusters across samples (WT, hTNFtg 4 and 8 weeks). C Table summarizing the cluster numbers, simplified names, and marker genes. D Dot plot of the cluster marker genes. The color of the dot shows the intensity of expression while the size denotes the percentage of cells expressing the gene in each cluster and condition (WT: wt-4w; hTNFtg/4: tg-4w; hTNFtg/8: tg-8w). E Functional enrichment analysis indicating the enriched biological processes for each cluster across samples. Significance is noted by color, and the percentage of cluster marker genes included in each term is noted by size

Back to article page

Genome Medicine

ISSN: 1756-994X

Contact us