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Fig. 7 | Genome Medicine

Fig. 7

From: Single-cell multimodal analysis identifies common regulatory programs in synovial fibroblasts of rheumatoid arthritis patients and modeled TNF-driven arthritis

Fig. 7

Integrative analysis of SFs from hTNFtg murine model and human RA pathology. A Integration of 24,042 RA patients’ SFs (3 different studies: Zhang et al. (2019), Wei et al. (2020), and Stephenson et al. (2018)) and our 3,051 hTNFtg SFs identified 7 SF clusters. UMAPs for the pooled human (downsampled to 3,051 cells) and mouse datasets, cells are colored by cluster identity. B Correlation heatmap (average expression of most variable genes) between human and mouse SF clusters. C Heatmap illustrating the significance of the selected enriched functional terms and pathways in human and mouse datasets. D Feature plots of selected marker genes commonly expressed between homologous human and mouse clusters of SF subpopulations

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Genome Medicine

ISSN: 1756-994X

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