Fig. 4

Somatic tumor evolution in three multifocal ileal NET patients. Upper panel represents the resected segments of ileum. Image from the patient 848 has been previously published under the terms of CC BY 4.0 as Fig. 1A in Zhang et al. [19]. Middle panel shows shared SNVs and indels between each tumor pair within a multifocal ileal NET patient. The somatic nature of the shared SNVs and indels was verified each time < 100 variants were shared between two tumors. Also, the presence of the shared variants in other tumors of the same patient was checked to avoid missing subclonal variants. Tumor sites are indicated by colored boxes. Bottom panel consists of somatic CNAs identified in each tumor. The CNAs are arranged in chromosome number order. Focal CNAs are marked with “F” to differentiate them from whole chromosome and whole chromosome arm events. Chromosome mapping was performed for chromosomes marked with an asterisk. P, primary tumor; M, metastasis