Fig. 2
From: A genetic model for central chondrosarcoma evolution correlates with patient outcome
Divergences in chronological and molecular age in chondrosarcoma. A Boxplots showing the distribution of age at diagnosis (n = 339) increasing across grades. Distributions differ across IDH1, IDH2, and IDHwt groups, with IDH2 tumours occurring in older patients compared to those with IDH1 and IDHwt tumours. B Boxplots of age, broken down by IDH status and grade. C The differences in chronological age between G2/3 IDH1 and IDH2 tumours and IDHwt tumours (B) is recapitulated in the activities of mutational signature SBS5. There is no significant difference in molecular age of IDH1 and IDH2 tumours, whereas there is a significant difference in the chronological age