Fig. 3

Microbial functional pathways related to survival in tumor and normal lung from stage II NSCLC patients. a For functional pathways selected >125 times in 500 × 10-fold cross-validated elastic-net penalized Cox regression and with FDR-adjusted q < 0.20 in either the tumor (n = 39) or normal lung (n = 41) data, we show number of times selected out of 500 times, and the hazard ratio (95% CI) from Cox proportional hazards regression of RFS, DFS, or OS on clr-transformed pathway abundance, adjusted for age, sex, race, histology, smoking status, and chemotherapy. b Spearman’s correlations between relative abundance of survival-related taxa and survival-related functional pathways in normal lung tissue data. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001