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Fig. 2 | Genome Medicine

Fig. 2

From: Whole-exome sequencing identifies novel protein-altering variants associated with serum apolipoprotein and lipid concentrations

Fig. 2

Rare variants in LIPC and RBM47 are associated with serum apoA1 and apoC-III concentrations, respectively. A LIPC p.Thr405Met (rs113298164) is associated with higher apoA1 (p=7.8×10−8; multivariable ANOVA p= 1.46×10−9; N=887 carriers, 31 non-carriers). Group number in A and C indicates the number of rare variants, i.e., 0 refers to non-carriers, 1 refers to heterozygous variant carriers. B LIPC p.Thr405Met associations across all studied phenotypes. C Serum apoC-III concentrations are reduced in the RBM47 p.Ala496-Ala502del (rs564837143) carriers (p=2.49×10−6, multivariable ANOVA p=2.92×10−4; N = 288 non-carriers, 6 carriers). D RBM47 p.Ala496-Ala502del associations across all studied phenotypes

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Genome Medicine

ISSN: 1756-994X

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