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Fig. 8 | Genome Medicine

Fig. 8

From: Spatiotemporal evolution of the clear cell renal cell carcinoma microenvironment links intra-tumoral heterogeneity to immune escape

Fig. 8

A hypothetical model for spatiotemporal evolution of ccRCC links ITH to immune escape and adverse TME. Cancer cell death, potentially by cytotoxic killing, early in tumor evolution selects for tumor clones with HLA LOH and/or CDKN2A/B loss. This promotes the evolution of a TME depleted of antigen-specific T cells and enriched for myeloid cells

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Genome Medicine

ISSN: 1756-994X

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