Risk assessment for colorectal cancer via polygenic risk score and lifestyle exposure: a large-scale association study of East Asian and European populations

Table 3 Cumulative risk of developing colorectal cancer according to different levels of PRS and lifestyle score in the UK Biobank cohort

PRS	Lifestyle	Cases/all	Incidence proportion (95% CI)	HR (95% CI)^a	P^a	P_trend	5-year absolute risk (reduction)^b
Low	Unfavorable	33/6650	0.50% (0.34, 0.70)	1.00 (reference)			0.28% (reference)
	Intermediate	47/14,338	0.33% (0.24, 0.44)	0.76 (0.48, 1.21)	0.248		0.19% (0.09%)
	Favorable	22/10,913	0.20% (0.13, 0.31)	0.55 (0.31, 0.98)	0.044	0.043	0.14% (0.14%)
Intermediate	Unfavorable	567/54,746	1.04% (0.95, 1.12)	1.00 (reference)			0.61% (reference)
	Intermediate	808/115,315	0.70% (0.65, 0.75)	0.78 (0.70, 0.87)	9.18E−06		0.42% (0.19%)
	Favorable	422/84,334	0.50% (0.45, 0.55)	0.64 (0.56, 0.73)	9.92E−11	7.18E−11	0.31% (0.31%)
High	Unfavorable	113/7030	1.61% (1.32, 1.93)	1.00 (reference)			1.07% (reference)
	Intermediate	180/14,406	1.25% (1.07, 1.45)	0.87 (0.68, 1.11)	0.255		0.75% (0.32%)
	Favorable	100/10,209	0.98% (0.80, 1.19)	0.77 (0.58, 1.03)	0.078	0.077	0.54% (0.53%)

PRS polygenic risk score, HR hazard ratio, 95% CI 95% confidence intervals
^aDerived from Cox regression model with the adjustment of sex, age, center, and first 10 principal components
^bMean value (reduction) of 5-year absolute risk

ISSN: 1756-994X