Fig. 4

SNP-based genome-wide association on gestational age. a Manhattan plot of the SNPs in GWAS. The red dash line represents the genome-wide significance level 4.515e−8. The SNP “rs946934582” with p-value of 2.764e−144 is beyond the scale, thus hereby listed alone. The genes shown are linking with the candidate SNPs and position of the corresponding genomic risk loci. b Functional annotation and enrichment test result of the candidate SNPs in FUMA. c A Venn diagram of the 166 genes that could be mapped to the 11 genomic risk loci by positional, eQTL and chromatin interaction strategies. d A Circos plot of the chromatin interactions and eQTL mapping in the 11 genomic risk loci from eight chromosomes. The outer ring is chromosomes, the regions in blue denote genomic risk loci. The middle ring represents the mapped genes. The color of the gene symbols shows how they were mapped, eQTL in green, chromatin interaction in orange, and both eQTL and chromatin interaction in black. The inner ring shows the linking edges, eQTL in green, and chromatin interaction in orange. e A summary of the 11 genomic risk loci