Fig. 6
From: Influence network model uncovers relations between biological processes and mutational signatures
Subnetworks of GSN for BRCA centered on (induced by) MutStates associated with Homologous Recombination, APOBEC and SBS8. Edge and node colors are as in Fig. 1. In boxes, there are the names of the genes adjacent to a given MutState with edge weight cut-off (\(|w_{ij}|\ge 0.01\)). The genes in bold are discussed in more detail in the text and the genes having bidirected interactions with MutStates are underlined. If the adjacent genes are enriched with specific GO pathways (\(q-value<0.01\)) then only the pathway genes are provided in the box. The HRD status dominantly contributes to the mutation strength in the DSB repair MutState. Increased DSB exposure leads to an increase of the exposures of APOBEC-C and (indirectly) APOBEC-D MutStates. SBS8 mutations are linked to the deficiency of nucleotide excision repair. The thickness of the arrows represents the edge weight (average edge weight if multiple genes are in a box). An extended subnetwork including all MutStates and an extended list of genes, and GO-terms are provided in Additional file 1: Fig. S3, Additional file 2: Table S2, and Additional file 3: Table S4