Fig. 2
From: Identification of specific susceptibility loci for the early-onset colorectal cancer
Manhattan plots for associations between genetic variants and EOCRC risk. A The logistic regression analysis of 1490 EOCRC cases and 19,951 controls. B The linear regression analysis with the independent variable being diagnosed age of 17,789 CRC cases. P values are two-sided, calculated by an additive model, and adjusted for sex, recruitment center, and the 10 principal components. The red line indicates the genome-wide significance threshold. The associations (–log10(P) values, y-axis) are plotted against genomic position (x-axis by chromosome and chromosomal position of NCBI build 37). C Manhattan plot shows the annotation of all 49 genetic risk variants independently (LD r2 < 0.6) associated with EOCRC risk in the GECCO cohorts. Gene indicates the mapped genes of variants. The red dots indicate the top two EOCRC risk variants: rs12137323 and rs12794623. The x-axis represents the –log10(P) values of the SNPs, and the y-axis represents the chromosomal positions. D Pathway enrichment analysis of target genes revealed that the majority are involved in several oncogenic pathways, such as chromatin assembly or disassembly and DNA replication (chromatin silencing and nucleosome assembly) (marked in red). E Disease association analysis of target genes by DisGeNET databases, and target genes are most significantly contributed to precancerous polyps (marked in red)